Two Simple, precise and economical methods have been developed and validated for the quantitative estimation of Ritonavir in bulk and pharmaceutical dosage forms. Method A includes analysis of Ritonavir by non aqueous titration using glacial acetic acid and per chloric acid. Method B includes estimation ritonavir by 0.1 N HCl at λ max of 243.5 with linearity range of 10-50 μg/mL. The developed method was validated according to ICH guidelines and was found to be accurate and precise. The proposed method can be successfully applied for the estimation of Ritonavir in bulk and pharmaceutical dosage forms. Results of the analysis were validated statistically and by recovery studies.
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